The versatility of cyclodextrins is further enhanced by their diverse synthetic and modification techniques. While natural cyclodextrins can be obtained through enzymatic conversion, numerous chemical methods enable the synthesis of modified cyclodextrins with altered properties. Functional groups can be introduced into the cyclodextrin structure, allowing for tailor-made properties to suit specific applications. These modified cyclodextrins exhibit enhanced solubility, selectivity, and host-guest interactions, expanding their utility in various industries.
Cyclodextrins have undoubtedly emerged as a highly versatile class of compounds, revolutionizing industries such as pharmaceuticals, food science, and environmental remediation. Their unique molecular structures, exceptional properties, and ability to form inclusion complexes have propelled them to the forefront of scientific research and technological advancements. As researchers continue to explore novel synthesis methods
Why modify cyclodextrins?
• Solubility improvement of the CD (and its complexes) in desired solvent, usually in water;
• better fit and/or association between the CD and its guest, with concomitant stabilization of the guest by changing its reactivity;
• more appropriate mimic of a binding site (e.g., in enzyme modeling) via attachment of specific groups; or
• formation of insoluble or immobilized CD-containing structures, polymers (e.g., for chromatographic purposes).